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Vaccine Development

HLA-A*0201 Recognizes Epitopes of Mycobacterium tuberculosis Protein Component

Published in Vaccine Weekly, January 24th, 2001

A study in HLA-transgenic mice has enabled researchers to identify epitopes of Mycobacterium tuberculosis Ag85B that could serve as subunit components in developing TB vaccines.

The scientists also determined that HLA class I-restricted, CD8+ T cells against Ag85B of M. tuberculosis are present in HLA-A2/K-b transgenic mice and HLA-A*0201+ humans.

Writing in the Journal of Immunology, A. Geluk and colleagues at Leiden University in The Netherlands explained that "epitopes for classical MHC class I-restricted CD8+ T cells, which most likely represent a majority among CD8+ T cells, have...

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