Fungal Infection

Gene Mutation Yields Attenuated Blastomyces Strain with Vaccine Potential

Published in Vaccine Weekly, January 31st, 2001

Researchers in the United States report that by mutating the WI-1 gene in the fungus Blastomyces dermatitidis, they have created an attenuated strain that stimulates protective immunity.

"Systemic fungal infections are becoming more common and difficult to treat, and vaccine prevention is not available," wrote M. Wuthrich and colleagues, University of Wisconsin. "Pulmonary infection with the dimorphic fungus Blastomyces dermatitidis often progresses and requires treatment to prevent fatality."

Wuthrich et al. published their study in the Journal of Clinical Investigation ("Mutation of the WI-1 gene yields an attenuated...

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Source: Vaccine Weekly (2001-01-31)

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