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Allergic Encephalomyelitis

Autoantigen-Pulsed Dendritic Cells Induces Tolerance in Experimental Model

Published in Vaccine Weekly, January 31st, 2001

An autoantigen-pulsed dendritic cell (DC) vaccine induced tolerance against experimental allergic encephalomyelitis (EAE) in a rat model, researchers in Sweden report.

"DC can modulate the nature of immune responses in a stimulatory or tolerogenic fashion," wrote Y.M. Huang and colleagues, Huddinge University Hospital, Karolinska Institute. "Great attention has been given to the induction of immunity to tumor and infection. In this study, bone marrow-derived DC from healthy Lewis rats were pulsed in vitro with encephalitogenic myelin basic protein peptide 68-86 (MBP 68-86), and injected subcutaneously (1x106/rat) into normal Lewis rats."

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