Cancer Vaccines

Cell-Based Gene Therapy Potentiates Rejection of Syngeneic Tumors

Published in Vaccine Weekly, January 31st, 2001

Cytotoxic T lymphocytes (CTL) epitopes shared by many cancer types may be potential therapeutic anticancer targets, researchers in Argentina report.

"Cell-based gene therapy after cytokine gene transfer is being investigated for autologous and allogeneic vaccination in cancer therapy," wrote S. Adris and colleagues, University Buenos Aires. "Here we show that mice vaccinated with 3-5x10⁶ interleukin 12 (IL-12) gene-transduced CT26 colon cancer cells developed a long-lasting antitumor immune memory able to reject not only parental cells but also syngeneic, LM3 mammary, and MCE fibrosarcoma tumorigenic cells."

Adris et al. published their...

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Source: Vaccine Weekly (2001-01-31)

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