Mucosal Vaccines

Vectors Expressing Cytokines Specifically Enhance Responses

Published in Vaccine Weekly, February 7th, 2001

- by Michelle Marble, staff medical writer -- Interleukin (IL)-5 and IL-6 enhance immune responses of mucosal vaccines, researchers in Canada say.

"In this study, we have examined the in vivo effects of IL-5 and IL-6 over-expression on systemic and mucosal immune responses using recombinant human type 5 adenoviruses capable of expressing these cytokines upon infection," wrote T.A. Braciak and colleagues, McMaster University, Ontario.

Braciak et al. published their study in the journal Immunology ("Recombinant adenovirus vectors expressing interleukin-5 and -6 specifically enhance mucosal immunoglobulin A responses in the lung," Immunol,...

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Source: Vaccine Weekly (2001-02-07)

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