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Cancer Vaccines

Protocol Elicits Anti-Carcinoembryonic Antigen Immune Responses

Published in Vaccine Weekly, February 7th, 2001

- by Michelle Marble, staff medical writer -- Results of a Phase I study of an anti-cancer vaccination protocol in advanced cancer patients indicates success in eliciting immune responses.

"This trial sought to determine, for the first time, the validity in human vaccinations of using two different recombinant vaccines in diversified prime-and-boost regimens to enhance T-cell responses to a tumor antigen," stated J.L. Marshall and colleagues, Georgetown University, Washington, DC. "Eighteen patients with advanced tumors expressing carcinoembryonic antigen (CEA) were randomized to receive either recombinant vaccinia (rV)-CEA followed by three avipox-CEA vaccinations, or...

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