Cancer Vaccines

DNA Immunization with Ras Oncogene Peptide Elicits T-Cell Responses

Published in Vaccine Weekly, February 14th, 2001

- by Michelle Marble, staff medical writer -- Researchers in the United States have discovered a ras oncogene peptide with anticancer potential.

"Mutations in ras proto oncogenes are commonly found in a diversity of malignancies and may encode unique, non-self epitopes for T-cell-mediated antitumor activity," stated J.A. Bristol and colleagues, U.S. National Cancer Institute, Bethesda, Maryland. "In a BALB/c (H-2^d) murine model, we have identified a single peptide sequence derived from the ras oncogenes that contained both CD8⁺ and CD4⁺ T-cell epitopes in a nested configuration."

Bristol et al. published the results...

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Source: Vaccine Weekly (2001-02-14)

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