Published in Vaccine Weekly, February 14th, 2001
"Immunization with irradiated autoreactive T cells (T-cell vaccination) induces anti-idiotypic T-cell responses that preferentially recognize complementarity-determining region 3 sequences, contributing to clonal depletion of autoreactive T cells," wrote J. Hong and colleagues, Baylor College of Medicine, Houston, Texas. "However, it remains unknown whether T-cell vaccination elicits anti-idiotypic humoral responses and whether the anti-idiotypic Abs play a similar role in the regulatory mechanism induced by T-cell...
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