Immunology

Anti-Idiotypic Humoral Responses Induced by T-Cell Vaccination

Published in Vaccine Weekly, February 14th, 2001

- by Michelle Marble, staff medical writer -- Humans can respond to T-cell vaccination with anti-idiotypic antibody (Ab) responses, neurologists report.

"Immunization with irradiated autoreactive T cells (T-cell vaccination) induces anti-idiotypic T-cell responses that preferentially recognize complementarity-determining region 3 sequences, contributing to clonal depletion of autoreactive T cells," wrote J. Hong and colleagues, Baylor College of Medicine, Houston, Texas. "However, it remains unknown whether T-cell vaccination elicits anti-idiotypic humoral responses and whether the anti-idiotypic Abs play a similar role in the regulatory mechanism induced by T-cell...

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Source: Vaccine Weekly (2001-02-14)

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