Vaccine Development

HLA Class I Polymorphism and Population Genetics Influence Response

Published in Vaccine Weekly, February 21st, 2001

by Michelle Marble, staff medical writer -- According to a study from the United States, genetic differences in populations influence vaccine efficacy.

"Human leukocyte antigen (HLA) polymorphism can complicate the design and development of vaccines, especially those that contain a selected number of epitopes and are directed at pathogens prevalent worldwide," wrotes D.V. Dawson and colleagues, Case Western Reserve University, Cleveland, Ohio. "Because of HLA class I restricted antigen recognition and ethnic variation in HLA distribution, such vaccines may not be uniformly effective across populations." Dawson et al. published the results of their study in the journal...

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Source: Vaccine Weekly (2001-02-21)

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