Meningitis

Revaccination May Result in Reduced Antibody Response

Published in Vaccine Weekly, February 21st, 2001

by Michelle Marble, staff medical writer -- According to a study from England, repeated immunization using meningococcal polysaccharide vaccines may actually reduce antibody response.

"Widespread use of meningococcal A and C polysaccharide (MACP) vaccines has raised concerns about induction of hyporesponsiveness to these polysaccharides," wrote R. Borrow and colleagues, Withington Hospital, in the journal Vaccine. "Immunological hyporesponsiveness to C polysaccharide has been clearly documented in infants, children, and adults but only limited data from Gambian children are available for A polysaccharide."

"We investigated whether a second...

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Source: Vaccine Weekly (2001-02-21)

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