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Asthma

Vaccine Prevents Hyper-Responsiveness In Mice

Published in Vaccine Weekly, March 21st, 2001

by N.R. Saltmarsh, staff medical writer -- Mice inoculated with bacillus Calmette-Guerin (BCG) vaccine 10 days after birth appear able to block an immune hyper-responsiveness characteristic of asthma by 16 weeks of age.

Researchers working in France explored the idea that asthma is an over-response of T-helper lymphocyte phenotype 2 (Th-2) in children who have not been previously exposed to Th-l-inducing infections.

"We tested the hypothesis that BCG vaccination in Th-2-susceptible newborn BP2 mice blocks allergic inflammation and bronchial hyper-reactivity (BHR)," explained M.A. Nahori and colleagues.

The researchers inoculated...

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