Leprosy

DNA Antigen May Lead To Development Of More Effective Vaccine

Published in Vaccine Weekly, March 28th, 2001

by N.R. Saltmarsh, staff medical writer - Immunization of mice with a DNA protein protects against leprosy infection at least as well as the Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccine currently in use.

Leprosy remains a worldwide problem despite vaccination with BCG, and development of new vaccines is imperative, said E. Martin and colleagues at the Centenary Institute for Cancer Medicine and Cell Biology in Washington, DC.

"The immune dominant 35 kDa protein, shared [by] Mycobacterium leprae and M. avium, but not M. tuberculosis or BCG, is recognized by >90% of leprosy patients, making it an ideal...

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Source: Vaccine Weekly (2001-03-28)

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