Published in Vaccine Weekly, March 28th, 2001
"We have investigated the use of plasmid DNA (pDNA) vaccination to elicit Th2 effector cell function in an antigen-specific manner and in turn prevent insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice," reported R. Tisch and colleagues at the University of North Carolina.
The researchers combined pDNA with a fusion protein consisting of a fragment of glutamic acid decarboxylase 65 (GAD65) linked to IgGFc...
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