Type 1 Diabetes

Plasmid DNA Vaccination Stops Disease Progression In Mice

Published in Vaccine Weekly, March 28th, 2001

by N.R. Saltmarsh, staff medical writer - Vaccination with plasmid DNA encoding glutamic acid decarboxylase 65, immunoglobulin GFc (IgGFc), and interleukin 4 (IL-4) appears able to stop the progression of diabetes in mice.

"We have investigated the use of plasmid DNA (pDNA) vaccination to elicit Th2 effector cell function in an antigen-specific manner and in turn prevent insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice," reported R. Tisch and colleagues at the University of North Carolina.

The researchers combined pDNA with a fusion protein consisting of a fragment of glutamic acid decarboxylase 65 (GAD65) linked to IgGFc...

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Source: Vaccine Weekly (2001-03-28)

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