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Vaccine Weekly

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Immunogenicity



Antibody Response Depends On Dose Of Inactivated Enterotoxigenic E. coli



April 11th, 2001

by N.R. Saltmarsh, staff medical writer - Researchers working in Sweden have developed an oral inactivated Escherichia coli vaccine that boosts circulating antibodies in a dose-dependent manner.

Marianne Jertborn and colleagues report that various preparations of oral inactivated enterotoxigenic E. coli (ETEC) vaccine stimulated immune response in Swedish volunteers who had never been exposed to E. coli.

They vaccinated subjects with cholera toxin B subunit (CTB) and various amounts of formalin-killed whole E. coli bacteria expressing the most prevalent colonization factor antigens (CFAs). After the second dose of...


Source: Vaccine Weekly (2001-04-11)

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