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Lyme Disease
DNA Vaccine Prevents But Does Not Cure Infection
April 11th, 2001
by N.R. Saltmarsh, staff medical writer - A DNA vaccine combining outer surface proteins (Osp) of Borrelia burgdorferi is able to stimulate antibody protection against future infection with Lyme disease but not to resolve existing infection, report immunologists. Previous studies had shown that vaccination with OspA could prevent, but not cure infection with Borrelia burgdorferi, while passive transfer of antibodies to OspC could cure infection. "In the present study, DNA vaccines encoding either the OspC antigen alone or fused to OspA and under the transcriptional control of the human elongation factor 1(alpha) promoter were evaluated...
Source: Vaccine Weekly (2001-04-11)
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