Drug Delivery

Oral Vaccine Development Gets A Shot In The Arm From Chitosan Microparticles

Published in Vaccine Weekly, April 18th, 2001

by N.R. Saltmarsh, staff medical writer - Microparticles that can entrap vaccine and then release it in the gastrointestinal tract represent an exciting potential carrier for oral immunization, say researchers working in The Netherlands.

Oral vaccination is highly desirable in terms of cost, safety, and appeal, but until now, oral delivery has suffered from low bioavailability and a lack of uptake in intestinal lymph tissues.

I.M. van der Lubben and colleagues proposed that chitosan microparticles offer a unique vehicle for vaccine delivery because they are small enough to be absorbed by Peyer's patches in mice and bioavailable enough to release...

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Source: Vaccine Weekly (2001-04-18)

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