Published in Vaccine Weekly, April 18th, 2001
C. Grangett and colleagues at Institut Pasteur wanted to test the proposal that using live microorganisms to carry antigens could elicit immune responses that translated to disease protection. They used Lactobacillus bacteria to deliver tetanus vaccine because of their established safety profile in humans and their high immunogenicity.
"To determine whether an immune response could be elicited by intranasal delivery of...
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