Tetanus

Vaccine Incorporating Lactobacillus Carrier Protects Mice From Lethal Challenge

Published in Vaccine Weekly, April 18th, 2001

by N.R. Saltmarsh, staff medical writer - Immunizing mice with live Lactobacillus plantarum carrying a tetanus toxin protected them from a subsequent lethal injection of tetanus, say researchers working in France.

C. Grangett and colleagues at Institut Pasteur wanted to test the proposal that using live microorganisms to carry antigens could elicit immune responses that translated to disease protection. They used Lactobacillus bacteria to deliver tetanus vaccine because of their established safety profile in humans and their high immunogenicity.

"To determine whether an immune response could be elicited by intranasal delivery of...

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Source: Vaccine Weekly (2001-04-18)

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