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Toxoplasmosis

Enterotoxin Vaccine Protects Against Intestinal Parasite

Published in Vaccine Weekly, April 18th, 2001

by N.R. Saltmarsh, staff medical writer - A mutated, nontoxic, heat-labile enterotoxin appears to be an effective carrier for Toxoplasma gondii vaccine in mice.

Animals vaccinated with two versions of the vaccine showed a decrease in cerebral tumors caused by challenge with T. gondii.

C. Bonenfant and colleagues wanted to test LTR72 and LTK63, two nontoxic mutant enterotoxins, for vaccine delivery, proposing that their strong mucosal activities would induce a long-lasting immunogenic response.

When they vaccinated mice with LTR72 and LTK63 plus T. gondii SAG1 protein, Bonenfant et al. observed high-level...

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