Vaccine Development

Pneumococcal Polysaccharide Antigens Upregulate Immune Response In Children

Published in Vaccine Weekly, May 16th, 2001

by N.R. Saltmarsh, staff medical writer - Pneumococcal polysaccharide antigens increase CD40 ligand (CD40L) and T helper 2 (Th2) expression both in vitro and in children receiving the pneumococcal vaccine, study results show.

"We wished to determine whether pneumococcal polysaccharide antigens induce mRNA expression of CD40L and Th1 or Th2 cytokines in unimmunized individuals in vitro and whether immunization with the 23-valent pneumococcal polysaccharide vaccine induces changes in CD40L and cytokine mRNA expression," said L.E. Leiva and colleagues at Louisiana State University.

They measured serum and in vitro immune responses for children with...

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Source: Vaccine Weekly (2001-05-16)

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