Delivery Systems

Adding Bile Salts To Oral Vaccines Stimulates Potent Immune Response

Published in Vaccine Weekly, June 6th, 2001

by N.R. Saltmarsh, staff medical writer - Incorporating bile salts into nonionic surfactant vesicles boosts the potency of oral vaccines and may ultimately provide oral alternatives to current parenteral vaccines.

M. Conacher and scientists working in Scotland said that deoxycholate was the most effective bile salt and called the new vesicles bilosomes.

Conacher and team tested the bilosomes with a standard antigen, a synthetic measles peptide, and an influenza subunit vaccine in mice, fine-tuning the protocol until they arrived at the ideal of two doses of vaccine three days apart, repeated two weeks later.

The oral measles...

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Source: Vaccine Weekly (2001-06-06)

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