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Intra-Spleen DNA Vaccine Stimulates Lymphoid Immune Response

Published in Vaccine Weekly, July 4th, 2001

by N.R. Saltmarsh, staff medical writer - A DNA vaccine administered to the spleen is capable of stimulating immune responses necessary for protective efficacy, according to a new report in DNA Cell Biology.

A. Cano and researchers in Mexico wanted to construct a vaccine that would deliver antigen-presenting cells or antigens into the lymphoid organs, a necessary step to induce protective immune responses in the host.

"We immunized mice by a single intraspleen (i.s.) injection of a DNA construct expressing the immunoglobulin (Ig) heavy-chain variable domain (V(H)) in which the complementarity-determining regions (CDR) had been replaced by a...

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Source: Vaccine Weekly (2001-07-04)

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