Published in Vaccine Weekly, July 4th, 2001
A. Cano and researchers in Mexico wanted to construct a vaccine that would deliver antigen-presenting cells or antigens into the lymphoid organs, a necessary step to induce protective immune responses in the host.
"We immunized mice by a single intraspleen (i.s.) injection of a DNA construct expressing the immunoglobulin (Ig) heavy-chain variable domain (V(H)) in which the complementarity-determining regions (CDR) had been replaced by a...
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