Adjuvants

GFP-A2/CTB Complexes Could Broaden Horizons Of Cholera Toxin-Based Vaccines

Published in Vaccine Weekly, July 25th, 2001

by N.R. Saltmarsh, staff medical writer - Researchers in the United States have come up with a novel method of assembling cholera toxin-like complexes in vitro, which could ultimately expand the potential of cholera toxin-based vaccines.

S.O. Hatic and colleagues, described the usefulness of cholera toxin as a mucosal adjuvant when coadministered with antigens and the current work on generating CT chimeras with reduced toxicity and better efficiency, in their paper in the journal Analytical Biochemistry.

"To date, chimeric forms of CT [cholera toxin] have been produced in bacterial strains by co-expressing the CT B subunit and a chimeric form...

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Source: Vaccine Weekly (2001-07-25)

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