Human Papillomavirus

Synthetic Peptides Cause Significant Lysis Of HPV Targets

Published in Vaccine Weekly, September 12th, 2001

by N.R. Saltmarsh, staff medical writer - Researchers in the United States have identified possible vaccine candidates for human papillomavirus (HPV), using an algorithm that may have applications in the development of other cancer immunotherapies.

"Over 90% of cervical carcinomas express human papillomavirus (HPV) E6 and E7 proteins, noted M.R. Castellanos and colleagues. "These unique antigens are ideal targets for the development of cytotoxic T-lymphocytes (CTL) for anti-tumor immunotherapy."

Castellanos and team created a computer-assisted algorithm to predict which peptides from HPV-18 E6 and E7 proteins might bind to HLA-A2 molecules,...

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Source: Vaccine Weekly (2001-09-12)

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