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Mucosal Administration Of GTF Proteins Induces Protective Response

Published in Vaccine Weekly, September 19th, 2001

by N.R. Saltmarsh, staff medical writer - Mucosal administration of peptide-based Streptococcus mutans glucosyltransferase (GTF) vaccines can induce immune responses that are potentially protective against dental caries, researchers in the United States have found.

If combined with the CT or LT R192G mucosal adjuvant, GTF vaccine facilitated mucosal and systemic immunity to S. mutans glucosyltransferase, reported D.J. Smith and colleagues at the Forsyth Institute, Boston.

"Synthetic peptide vaccines which are derived from functional domains of S. mutans GTF have been shown to induce protective immunity in Sprague-Dawley rats...

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Source: Vaccine Weekly (2001-09-19)

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