Vaccine Research

Transformed Bacteria Produce HCV-Specific Immune Response In Mice

Published in Vaccine Weekly, November 21st, 2001

by Sonia Nichols, senior medical writer - U.S. National Institutes of Health (NIH) researchers report they have transformed Salmonella bacteria so that it elicits an immune response against hepatitis C virus (HCV) DNA in HLA-A2.1 transgenic mice.

"We used an oral immunization strategy with attenuated HCV-NS3-transformed Salmonella typhimurium to deliver DNA directly to the gut-associated lymphoid tissue," described H. Wedemeyer and coauthors in the November 2001 issue of Gastroenterology.

After murine immunization, Wedemeyer and colleagues collected and analyzed any detectable HCV epitope-specific CD8⁺ T cells, using...

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Source: Vaccine Weekly (2001-11-21)

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