Gene Delivery

Urinary Bladder Approach Could Be Used For Vaccinia-Mediated Therapy

Published in Vaccine Weekly, December 26th, 2001

by Sonia Nichols, senior medical writer - The results of a Phase I trial indicate urinary bladder cancer and other diseases of the urinary tract could be treated by directly infecting the bladder with vaccinia virus, the same virus used in vaccines for preventing smallpox.

The properties of vaccinia virus make it a good candidate for use in bladder-directed gene therapies, according to Leonard G. Gomella and colleagues, Thomas Jefferson University, Philadelphia, Pennsylvania.

"The virus has a high efficiency of infection, replicates in the cytoplasm without chromosomal integration, and can transport a large amount of recombinant DNA," Gomella and...

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Source: Vaccine Weekly (2001-12-26)

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