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Vaccine Adjuvants

Transduced Dendritic Cells Inspire Antitumor Effect

Published in Vaccine Weekly, January 9th, 2002

by Sonia Nichols, senior medical writer - A growing body of evidence continues to point to transduced dendritic cells as important adjuvants for tumor vaccines.

"Gene delivery to dendritic cells provides an intracellular source of antigen for efficient and persistent loading to MHC class I molecules capable of activating CD8+ CTLs, which play a central role in antitumor immunity," N. Okada and colleagues, Kyoto Pharmaceutical University, Japan, described in a recent report.

To date, attempts at efficient dendritic cell transduction have met with many failures and some successes. Okada and colleagues have performed research suggesting the...

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