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AIDS and HIV Vaccine

Interleukins Can Be Effective Adjuvants For Mucosal Administration

Published in Vaccine Weekly, January 16th, 2002

by Michael Greer, senior medical writer - A group of proinflammatory cytokines may be useful as adjuvants for nasally administered HIV vaccines, researchers in the United States report.

"Safe and potent new adjuvants are needed for vaccines that are administered to mucosal surfaces," according to Curtis P. Bradney and colleagues at Duke University Medical Center's Departments of Medicine, Human Vaccine Institute, and Center for AIDS Research in Durham, North Carolina.

Several interleukins in combination significantly enhanced the efficacy of a vaccine candidate, to a higher degree than other potential adjuvants, Bradney and coauthors found.

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