Autoantigen

Interleukin-4 Makes End-Run Around Autoaggression After DNA Immunization

Published in Vaccine Weekly, February 20th, 2002

by Sonia Nichols, senior medical writer - Giving prophylactic doses of interleukin (IL)-4 may be one way to avoid overly active immune system responses sometimes observed following DNA immunizations with autoantigens.

DNA immunizations have been proposed as one of several methods for preventing or treating type 1 diabetes, which arises as a result of the body recognizing pancreatic cells as foreign antigens.

"Administration of autoantigens through DNA immunizations or via the oral route can prevent progression of islet destruction and lower the incidence of type 1 diabetes in animal models," T. Wolfe and colleagues, the Scripps Research Institute, La...

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Source: Vaccine Weekly (2002-02-20)

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