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Cytomegalovirus

DNA vaccine provides long-term protection

Published in Vaccine Weekly, May 8th, 2002

by Michael Greer, senior medical writer - Researchers in the United States say that an enhanced DNA vaccine against cytomegalovirus (CMV) offers long-term protection from viral proliferation.

"We previously demonstrated that immunization of mice with plasmid DNAs (pDNAs) expressing the murine cytomegalovirus (MCMV) genes IE1-pp89 and M84 provided synergistic protection against sublethal viral challenge, while immunization with plasmids expressing putative virion proteins provided no or inconsistent protection," explained Dr. Christopher Morello and colleagues at the University of California-San Diego in La Jolla, California.

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