Herpesvirus

Stress reduces mucosal immunity against herpes simplex virus

Published in Vaccine Weekly, June 12th, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Psychological stress has been shown to inhibit the protective effects of vaccination against herpes simplex virus (HSV) in mice mucosa.

"Psychological stress has been shown to affect many components of the innate and adaptive immune responses to a variety of pathogens including herpes simplex virus," said study coauthors R. H. Bonneau and K. M. Wonnacott from the Hershey Medical Center in Hershey, Pennsylvania. "However, there is a scarcity of experimental evidence that stress affects mucosal immunity."

Investigators used a murine model in which HSV-specific immunity is conferred only by one type...

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Source: Vaccine Weekly (2002-06-12)

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