Published in Vaccine Weekly, June 19th, 2002
K. Kontani and colleagues at Shiga University of Medical Science in Japan immunized C57BL/6 mice with a DNA vaccine that encoded for MUC1 polypeptide. Upon challenge with EL4-muc, MUC1-transfected syngeneic lymphoma cells, the immunized mice rejected the tumors. However, the DNA vaccine was unable to prevent progression of tumor growth in EL4-muc tumor-bearing mice.
"This animal model is useful for developing DNA...
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