Vaccine Development

Herpes simplex virus aids treatment for metastatic brain tumors

Published in Vaccine Weekly, June 19th, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Researchers in Tokyo have infected metastatic brain tumors with a replication-conditional type of herpes simplex virus (HSV) and saw stimulation of anti-HSV T cells that induced antitumor effects.

Treatment of brain cancer is complicated by being located in an immunologically privileged location of the central nervous system. M. Toda and colleagues at the Institute for Advanced Medical Research in Tokyo used BALB/c mice, which produce intracranial and subcutaneous mouse CT26 colon adenocarcinoma tumors, for testing a novel approach to brain cancer treatment.

The researchers injected a...

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Source: Vaccine Weekly (2002-06-19)

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