Published in Vaccine Weekly, July 3rd, 2002
The expression of sperm antigen 17 (Sp17) in normal tissue is limited. Therefore, it holds potential as a vaccine target for diseased tissues that do express the antigen.
M. Chirivainternati and colleagues at the Don and Sybil Harrington Cancer Center in Amarillo, Texas, prepared cytotoxic T-lymphocytes (CTL) specific to Sp17 after determining the gene expression of Sp17. A 51Cr release assay confirmed the identity of the CTLs.
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