Cancer Vaccine

Myeloid suppressor cells prevent tumor immunotherapy efficacy

Published in Vaccine Weekly, August 21st, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Myeloid suppressor cells (MSC) appear to inhibit the T-cell response normally mounted against tumor cells, allowing and even promoting tumor growth, according to a report in the journal Cancer Immunology, Immunotherapy.

Robert M. Prins and his associates at Virginia Commonwealth University inoculated rats with T9 glioma cells (5x10⁴) intracranially (i.c.) and allowed the tumors to grow for 5 days. On the fifth day, the animals received subcutaneous vaccination with irradiated T9.F glioma cells (5x10⁶). The investigators found that vaccination actually shortened survival time compared with...

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Source: Vaccine Weekly (2002-08-21)

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