Cancer Vaccine

Tumor cells overexpressing heat shock protein effectively inhibit murine colon cancer growth

Published in Vaccine Weekly, October 16th, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Growth of a murine CT26 colon carcinoma was completely inhibited by immunization of the mice with a vaccine containing a heat shock protein and cells that produced granulocyte-macrophage colony stimulating factor (GM-CSF).

"Several studies have suggested a positive correlation between heat shock protein (hsp) expression and tumor immunogenicity," commented Xiang-Yang Wang and colleagues at the Roswell Park Cancer Institute in Buffalo, New York. "Independently, many studies have shown that hsp purified from tumors can be used as a tumor-specific vaccine."

The investigators incorporated the cDNA of...

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Source: Vaccine Weekly (2002-10-16)

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