Melanoma

Dead tumor cells improve melanoma vaccine immunogenicity

Published in Vaccine Weekly, October 16th, 2002

by Maria G. Essig, MS, ELS, senior medical writer - A higher number of dead tumor cells in a vaccine containing autologous melanoma tumor cells increased the delayed-type hypersensitivity response in melanoma patients, according to investigators in the U.S.

"We have reported that treatment of melanoma patients with a vaccine consisting of autologous tumor cells modified with the hapten, dinitrophenyl (DNP) and preceded by low-dose cyclophosphamide induces delayed-type hypersensitivity (DTH) to autologous, unmodified tumor cells and that this response is a significant predictor of survival," said David Berd and colleagues at Thomas Jefferson University in...

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Source: Vaccine Weekly (2002-10-16)

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