Stroke

Vaccine offers protection in rats

Published in Vaccine Weekly, October 30th, 2002

A vaccine that interferes with inflammation inside blood vessels greatly reduces the frequency and severity of strokes in spontaneously hypertensive, genetically stroke-prone rats, according to a new study from the U.S. National Institutes of Health's National Institute of Neurological Disorders and Stroke (NINDS). If the vaccine works in humans, it could prevent many of the strokes that occur each year.

In the study, researchers used a nasal spray to deliver a protein that, under normal circumstances, contributes to inflammation of the cells that line the inner walls of blood vessels. Exposing rats to this substance, called E-selectin, programs blood cells called...

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Source: Vaccine Weekly (2002-10-30)

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