Published in Vaccine Weekly, November 6th, 2002
Patricia Londono-Arcila and colleagues at Acambis, Ltd., in Cambridge, England, used a plasmid containing ureAB genes to generate CVD908 and CVD908-htrA strains of S. enterica serovar Typhi that expressed an H. pylori urease. These vaccine strains were able to replicate, infect human monocytes, and colonize mouse lungs.
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