Helicobacter Pylori Vaccine

Salmonella enterica Typhi vaccine protects against H. pylori infection

Published in Vaccine Weekly, November 6th, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Protection against Helicobacter pylori was provided by a vaccination regimen that combined a primary intranasal inoculation with a strain of Salmonella enterica serovar Typhi expressing an H. pylori urease followed by a parenteral boost.

Patricia Londono-Arcila and colleagues at Acambis, Ltd., in Cambridge, England, used a plasmid containing ureAB genes to generate CVD908 and CVD908-htrA strains of S. enterica serovar Typhi that expressed an H. pylori urease. These vaccine strains were able to replicate, infect human monocytes, and colonize mouse lungs.

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Source: Vaccine Weekly (2002-11-06)

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