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Women's Health

HPV16 antibodies cause regression of cervical neoplasia

Published in Vaccine Weekly, November 6th, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Neutralizing antibodies against human papillomavirus 16 (HPV16) appear to cause regression of cervical intraepithelial (CIN) lesions and may even eliminate lesions in some cases.

Kei Kawana and colleagues at the University of Tokyo assigned 76 women to one of four categories based upon their cervical pathology, normal (n=7), CIN1 (n=37), CIN2 or CIN3 (n=19), or cervical cancer (n=13). Serum samples from the subjects were tested for neutralizing antibodies against HPV16 using HPV16-pseudovirions.

Women with normal cervical pathology were significantly more likely (p<0.0001) to have HPV16...

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