Cancer Vaccine

Stromal cell-derived factor 1 effective against leukemia and melanoma in murine models

Published in Vaccine Weekly, November 20th, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Vaccination with irradiated tumor cells expressing stromal cell-derived factor 1 (SDF-1) prevented tumor growth in tumor cell-challenged naive mice and eliminated established tumors, according to reasearchers in the U.S.

"The chemokine stromal cell-derived factor 1 (SDF-1) is essential for perinatal viability, B lymphopoiesis, and bone marrow myelopoiesis, and is a potent monocyte and T-lymphocyte chemoattractant," explained Kyriaki Dunussi-Joannopoulos and colleagues at Wyeth Research and the American Red Cross Holland Laboratory in the U.S. "Interactions of SDF-1 with its receptor CXCR4 have been implicated in CD34+...

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Source: Vaccine Weekly (2002-11-20)

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