Human Papillomavirus

Virus-like particles do not activate Langerhans cells

Published in Vaccine Weekly, December 4th, 2002

Langerhans cells are not activated by human papillomavirus (HPV) virus-like particles, report cancer researchers, who say this suggests a possible "immune escape mechanism" used by HPV.

"High-risk human papillomaviruses are linked to several malignancies including cervical cancer. Because human papillomavirus-infected women do not always mount protective antiviral immunity, we explored the interaction of human papillomavirus with Langerhans cells, which would be the first APCs [antigen-presenting cells] the virus comes into contact with during infection," stated S.C. Fausch and colleagues, Loyola University, Cardinal Bernardin Cancer Center.

The...

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Source: Vaccine Weekly (2002-12-04)

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