Vaccine Adjuvant
Flagellin acts as potent adjuvant
Published in Vaccine Weekly, December 25th, 2002
"Flagellin is secreted by many enteric bacteria and, upon reaching the basolateral membrane of the intestinal epithelium, activates Toll-like receptor 5-mediated innate immune signaling pathways," explained Stephen J. McSorley and colleagues at the Universities of Minnesota and Connecticut and at Emory University. "We hypothesized that any flagellin that gets beyond the epithelium might also regulate cells of the adaptive immune system."
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Source: Vaccine Weekly (2002-12-25)
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