Gastroenterology Vaccine

Vaccine stimulates proliferation of cells able to home in on gut

Published in Vaccine Weekly, December 25th, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Oral delivery of a Salmonella vaccine in humans stimulated the proliferation of antigen-specific cytotoxic T cells that expressed integrin beta₇ and so were capable of homing in on the gut mucosa.

"The kinetics and homing characteristics of T-cell responses in humans after mucosal immunizations have not been well characterized," commented B. Samuel Lundin and colleagues at Goteborg University in Sweden. "Therefore, we have investigated the magnitude and duration of such responses as well as the homing receptor expression of antigen-specific peripheral blood T cells by using an oral model vaccine -...

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Source: Vaccine Weekly (2002-12-25)

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