Respiratory Syncytial Virus
Macaque model used to assess safety of nonreplicating candidate RSV vaccines
Published in Vaccine Weekly, January 8th, 2003
R.L. Deswart and colleagues, Erasmus MC, Institute of Virology, Netherlands, pointed out that RSV "is a major cause of severe respiratory disease in infants and the elderly. RSV vaccine development has been hampered by results of clinical trials in the 1960s, when formalin-inactivated whole-RSV preparations adjuvated with alum (FI-RSV) were found to predispose infants for enhanced disease following subsequent natural RSV infection."
In their study, the virologists "reproduced this...
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Source: Vaccine Weekly (2003-01-08)
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