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HIV/AIDS Vaccine

Modified rabies virus vectors safe, effective

Published in Vaccine Weekly, January 8th, 2003

by Michael Greer, senior medical writer - Novel rabies virus (RV)-based vaccines can safely protect animals against HIV infection, researchers in the United States report.

RV-based vectors "show great promise as vaccines against other viral diseases such as human immunodeficiency virus type 1 (HIV-1) infection and hepatitis C, but a low residual pathogenicity remains a concern for their use," explained James P. McGettigan and colleagues at Thomas Jefferson University in Philadelphia.

A series of second-generation RV-based vaccines have been rendered apathogenic without sacrificing their antiviral efficacy, McGettigan and coauthors said.

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