Allergy Medicine

Maternally transferred monoclonal IgG induce IgE unresponsiveness in mice

Published in Vaccine Weekly, January 22nd, 2003

If findings from a study conducted in mice hold true for humans, researchers think "maternally transferred or neonatally injected allergen-specific monoclonal antibodies in combination with natural or prophylactic exposure to the respective allergens during early childhood" could be a new strategy to prevent allergy and asthma.

"IgE [immunoglobulin E] is an important trigger in allergy and asthma, diseases whose development is suggested to depend on an initial sensitization in early life. While induction of murine IgE responses requires both a genetically-based IgE high responder phenotype and defined experimental conditions, maternally transferred IgG can override...

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Source: Vaccine Weekly (2003-01-22)

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