Animal Models

Quantitative assay could aid vaccine development in guinea pig models

Published in Vaccine Weekly, January 22nd, 2003

According to researchers in Japan, "The guinea pig has been utilized as a model for studying infectious diseases because its reactions closely resemble those of humans biologically and immunologically. However, the cytokine responses in this animal remain to be studied."

M. Kawahara and colleagues set out to do this, first developing "a quantitative assay using a real-time reverse transcription-PCR (RT-PCR) to measure guinea pig gamma interferon (IFN-gamma), interleukin-12 (IL-12), IL-10, and transforming growth factor beta (TGF-beta) mRNA."

"By preparing primer-fluorogenic probe sets for these cytokines and standard RNA templates corresponding to...

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Source: Vaccine Weekly (2003-01-22)

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