DNA Vaccines

Salivary gland delivery of pDNA-cationic lipoplexes is immunogenic

Published in Vaccine Weekly, January 22nd, 2003

Researchers in the United States tested "the ability of two cationic lipoplexes, Vaxfectin and GAP-DLRIE/DOPE, to facilitate transfection and elicit immune responses from plasmid DNAs (pDNAs) after retrograde instillation into salivary glands."

"Two pDNA expression vectors encoding either the influenza NP protein or human growth hormone (hGH) were complexed with the cationic lipid transfection reagents, GAP-DLRIE/DOPE or Vaxfectin, and delivered to the submandibular glands of rats.

"Samples from rats receiving the influenza NP protein pDNA and cationic lipoplexes were analyzed for anti-influenza NP-specific IgG1 [immunoglobulin G 1], IgG2a, and IgG2b...

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Source: Vaccine Weekly (2003-01-22)

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