Leishmaniasis

Immunotherapeutic antigens encapsulated in liposomes characterized

Published in Vaccine Weekly, January 22nd, 2003

According to a study from India, "Leishmania donovani promastigote membrane antigens (LAg) encapsulated in positively charged liposomes have been found to induce very significant levels of protection against experimental visceral leishmaniasis."

F. Afrin and colleagues report that "protectively immunized [BALB/c mice] exhibited profound delayed-type hypersensitivity and antibody responses."

"The extent of protection induced by the same antigens, however, varied depending on the charge of the vesicles, with maximum induction by positively charged liposomes, followed by neutral liposomes and last negatively charged liposomes," the researchers...

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Source: Vaccine Weekly (2003-01-22)

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